Description
Product Characteristics:
Description: Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.
Gene: CCBE1
Target Information: This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010]